Modulation of resting brain cerebral blood flow by the GABA B agonist, baclofen: A longitudinal perfusion fMRI study

BACKGROUND: Preclinical studies confirm that the GABA B agonist, baclofen blocks dopamine release in the reward-responsive ventral striatum (VS) and medial prefrontal cortex, and consequently, blocks drug motivated behavior. Its mechanism in humans is unknown. Here, we used continuous arterial spin...

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Main Authors: Franklin, Teresa R., Wang, Ze, Sciortino, Nathan, Harper, Derek, Li, Yin, Hakun, Jonathan, Kildea, Susan, Kampman, Kyle, Ehrman, Ron, Detre, John A., O’Brien, Charles P., Childress, Anna Rose
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348615/
https://ncbi.nlm.nih.gov/pubmed/21333466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2011.01.015
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