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Catalysis by a de novo zinc-mediated protein interface: implications for natural enzyme evolution and rational enzyme engineering
Here we show that a recent computationally designed zinc-mediated protein interface is serendipitously capable of catalyzing carboxyester and phosphoester hydrolysis. Although the original motivation was to design a de novo zinc-mediated protein-protein interaction (called MID1-zinc), we observed in...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3348550/ https://ncbi.nlm.nih.gov/pubmed/22510088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201881p |
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