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The nature of enzyme catalysis in trypsin.

We present a combined quantum/molecular mechanical study of the trypsin-catalyzed hydrolysis of a specific tripeptide substrate, including the entire enzyme in the calculation, as well as 200 H2O molecules. The results illustrate how the enzyme and nearby H2O molecules stabilize the ionic intermedia...

詳細記述

保存先:
書誌詳細
主要な著者: Weiner, S J, Seibel, G L, Kollman, P A
フォーマット: Artigo
言語:Inglês
出版事項: 1986
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC322921/
https://ncbi.nlm.nih.gov/pubmed/3456162
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