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Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H(+):Cl(−) exchanger

Active exchangers dissipate the gradient of one substrate to accumulate nutrients, export xenobiotics and maintain cellular homeostasis. Mechanistic studies suggested that all exchangers share two fundamental properties: substrate binding is antagonistic and coupling is maintained by preventing shut...

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Detalhes bibliográficos
Main Authors: Picollo, Alessandra, Xu, Yanyan, Johner, Niklaus, Bernèche, Simon, Accardi, Alessio
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348462/
https://ncbi.nlm.nih.gov/pubmed/22484316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2277
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