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NEDD8 links Cullin–Ring ubiquitin Ligase function to the p97 pathway

The AAA ATPase p97 and its UBA-UBX cofactors are thought to extract ubiquitinated proteins from membranes or protein complexes as a prelude to their degradation. However, ubiquitinated targets have not yet been identified for many cofactors, leaving their biological function unclear. Previous analys...

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Hlavní autoři: den Besten, Willem, Verma, Rati, Kleiger, Gary, Oania, Robert S., Deshaies, Raymond J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348432/
https://ncbi.nlm.nih.gov/pubmed/22466964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2269
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