Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy

Elevated aerobic glycolysis in cancer cells (the Warburg effect) may be attributed to respiration injury or mitochondrial dysfunction, but the underlying mechanisms and therapeutic significance remain elusive. Here we report that induction of mitochondrial respiratory defect by tetracycline-controll...

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Autors principals: Lu, Weiqin, Hu, Yumin, Chen, Gang, Chen, Zhao, Zhang, Hui, Wang, Feng, Feng, Li, Pelicano, Helene, Wang, Hua, Keating, Michael J., Liu, Jinsong, McKeehan, Wallace, Wang, Huamin, Luo, Yongde, Huang, Peng
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348157/
https://ncbi.nlm.nih.gov/pubmed/22589701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001326
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