A carregar...
K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis
Increased aerobic glycolysis and oxidative stress are important features of cancer cell metabolism, but the underlying biochemical and molecular mechanisms remain elusive. Using a tetracycline inducible model, we show that activation of K-ras(G12V) causes mitochondrial dysfunction, leading to decrea...
Na minha lista:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3257361/ https://ncbi.nlm.nih.gov/pubmed/21876558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.145 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|