K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

Increased aerobic glycolysis and oxidative stress are important features of cancer cell metabolism, but the underlying biochemical and molecular mechanisms remain elusive. Using a tetracycline inducible model, we show that activation of K-ras(G12V) causes mitochondrial dysfunction, leading to decrea...

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Detalhes bibliográficos
Main Authors: Hu, Yumin, Lu, Weiqin, Chen, Gang, Wang, Peng, Chen, Zhao, Zhou, Yan, Ogasawara, Marcia, Trachootham, Dunyaporn, Feng, Li, Pelicano, Helene, Chiao, Paul J, Keating, Michael J, Garcia-Manero, Guillermo, Huang, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257361/
https://ncbi.nlm.nih.gov/pubmed/21876558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.145
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