A Role of Template Cleavage in Reduced Excision of Chain-Terminating Nucleotides by Human Immunodeficiency Virus Type 1 Reverse Transcriptase Containing the M184V Mutation

Resistance to nucleoside reverse transcriptase (RT) inhibitors is conferred on human immunodeficiency virus type 1 through thymidine analogue resistance mutations (TAMs) that increase the ability of RT to excise chain-terminating nucleotides after they have been incorporated. The RT mutation M184V i...

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Main Authors: Acosta-Hoyos, Antonio J., Matsuura, Suzanne E., Meyer, Peter R., Scott, Walter A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347382/
https://ncbi.nlm.nih.gov/pubmed/22379084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05767-11
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