Efficient Nef-Mediated Downmodulation of TCR-CD3 and CD28 Is Associated with High CD4(+) T Cell Counts in Viremic HIV-2 Infection

The role of the multifunctional accessory Nef protein in the immunopathogenesis of HIV-2 infection is currently poorly understood. Here, we performed comprehensive functional analyses of 50 nef genes from 21 viremic (plasma viral load, >500 copies/ml) and 16 nonviremic (<500) HIV-2-infected in...

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Detalhes bibliográficos
Main Authors: Khalid, Mohammad, Yu, Hangxing, Sauter, Daniel, Usmani, Shariq M., Schmokel, Jan, Feldman, Jerome, Gruters, Rob A., van der Ende, Marchina E., Geyer, Matthias, Rowland-Jones, Sarah, Osterhaus, Albert D., Kirchhoff, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347365/
https://ncbi.nlm.nih.gov/pubmed/22345473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06856-11
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