Inefficient Nef-Mediated Downmodulation of CD3 and MHC-I Correlates with Loss of CD4(+) T Cells in Natural SIV Infection

Recent data suggest that Nef-mediated downmodulation of TCR-CD3 may protect SIVsmm-infected sooty mangabeys (SMs) against the loss of CD4(+) T cells. However, the mechanisms underlying this protective effect remain unclear. To further assess the role of Nef in nonpathogenic SIV infection, we cloned...

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Main Authors: Schindler, Michael, Schmökel, Jan, Specht, Anke, Li, Hui, Münch, Jan, Khalid, Mohammad, Sodora, Donald L., Hahn, Beatrice H., Silvestri, Guido, Kirchhoff, Frank
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2444047/
https://ncbi.nlm.nih.gov/pubmed/18636106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000107
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