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Inefficient Nef-Mediated Downmodulation of CD3 and MHC-I Correlates with Loss of CD4(+) T Cells in Natural SIV Infection
Recent data suggest that Nef-mediated downmodulation of TCR-CD3 may protect SIVsmm-infected sooty mangabeys (SMs) against the loss of CD4(+) T cells. However, the mechanisms underlying this protective effect remain unclear. To further assess the role of Nef in nonpathogenic SIV infection, we cloned...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2444047/ https://ncbi.nlm.nih.gov/pubmed/18636106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000107 |
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