Attenuated Influenza Virus Construct with Enhanced Hemagglutinin Protein Expression

Influenza A viruses encoding an altered viral NS1 protein have emerged as promising live attenuated vaccine platforms. A carboxy-terminal truncation in the NS1 protein compromises its interferon antagonism activity, making these viruses attenuated in the host yet still able to induce protection from...

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Dettagli Bibliografici
Autori principali: Maamary, Jad, Pica, Natalie, Belicha-Villanueva, Alan, Chou, Yi-ying, Krammer, Florian, Gao, Qinshan, García-Sastre, Adolfo, Palese, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347287/
https://ncbi.nlm.nih.gov/pubmed/22398291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00190-12
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