RNA Interference-Mediated Targeting of Human Cytomegalovirus Immediate-Early or Early Gene Products Inhibits Viral Replication with Differential Effects on Cellular Functions

Viral drug toxicity, resistance, and an increasing immunosuppressed population warrant continued research into new avenues for limiting diseases associated with human cytomegalovirus (HCMV). In this study, a small interfering RNA (siRNA), siX3, was designed to target coding sequences within shared e...

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Detalhes bibliográficos
Main Authors: E, Xiaofei, Stadler, Bradford M., Debatis, Michelle, Wang, Shixia, Lu, Shan, Kowalik, Timothy F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347265/
https://ncbi.nlm.nih.gov/pubmed/22438545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06338-11
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