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Alternative Splicing of the Human Cytomegalovirus Major Immediate-Early Genes Affects Infectious-Virus Replication and Control of Cellular Cyclin-Dependent Kinase

The major immediate-early (MIE) gene locus of human cytomegalovirus (HCMV) is the master switch that determines the outcomes of both lytic and latent infections. Here, we provide evidence that alteration in the splicing of HCMV (Towne strain) MIE genes affects infectious-virus replication, movement...

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Main Authors: Du, Guixin, Dutta, Nirmal, Lashmit, Philip, Stinski, Mark F.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020018/
https://ncbi.nlm.nih.gov/pubmed/21068259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01173-10
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