The 5′ Untranslated Region of the Major Immediate Early mRNA Is Necessary for Efficient Human Cytomegalovirus Replication

The human cytomegalovirus (HCMV) immediate early 1 (IE1) and IE2 proteins are critical regulators of virus replication. Both proteins are needed to efficiently establish lytic infection, and nascent expression of IE1 and IE2 is critical for reactivation from latency. The regulation of IE1 and IE2 pr...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Arend, Kyle C., Lenarcic, Erik M., Moorman, Nathaniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972869/
https://ncbi.nlm.nih.gov/pubmed/29343581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02128-17
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