The Canonical Immediate Early 3 Gene Product pIE611 of Mouse Cytomegalovirus Is Dispensable for Viral Replication but Mediates Transcriptional and Posttranscriptional Regulation of Viral Gene Products

Transcription of mouse cytomegalovirus (MCMV) immediate early ie1 and ie3 is controlled by the major immediate early promoter/enhancer (MIEP) and requires differential splicing. Based on complete loss of genome replication of an MCMV mutant carrying a deletion of the ie3-specific exon 5, the multifu...

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Bibliographic Details
Published in:J Virol
Main Authors: Rattay, Stephanie, Trilling, Mirko, Megger, Dominik A., Sitek, Barbara, Meyer, Helmut E., Hengel, Hartmut, Le-Trilling, Vu Thuy Khanh
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524224/
https://ncbi.nlm.nih.gov/pubmed/26063418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01234-15
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