In vitro evolution of a highly replicating, doxycycline-dependent HIV for applications in vaccine studies
A major concern associated with the use of vaccines based on live-attenuated viruses is the possible and well documented reversion to pathogenic phenotypes. In the case of HIV, genomic deletions or mutations introduced to attenuate viral pathogenicity can be repaired by selection of compensating mut...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2001
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33470/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11353837/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.111031498 |
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