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In vitro evolution of a highly replicating, doxycycline-dependent HIV for applications in vaccine studies

A major concern associated with the use of vaccines based on live-attenuated viruses is the possible and well documented reversion to pathogenic phenotypes. In the case of HIV, genomic deletions or mutations introduced to attenuate viral pathogenicity can be repaired by selection of compensating mut...

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Tallennettuna:
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Marzio, Giuseppe, Verhoef, Koen, Vink, Monique, Berkhout, Ben
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2001
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33470/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11353837/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.111031498
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