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In vitro evolution of a highly replicating, doxycycline-dependent HIV for applications in vaccine studies
A major concern associated with the use of vaccines based on live-attenuated viruses is the possible and well documented reversion to pathogenic phenotypes. In the case of HIV, genomic deletions or mutations introduced to attenuate viral pathogenicity can be repaired by selection of compensating mut...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC33470/ https://ncbi.nlm.nih.gov/pubmed/11353837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.111031498 |
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