Apolipoprotein E4 domain interaction accelerates diet-induced atherosclerosis in hypomorphic Arg-61 Apoe mice

OBJECTIVE: Apolipoprotein (apo) E4 is an established risk factor for atherosclerosis, but the structural components underlying this association remain unclear. ApoE4 is characterized by two biophysical properties: domain interaction and molten globule state. Substituting Arg-61 for Thr-61 in mouse a...

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Main Authors: Eberlé, Delphine, Kim, Roy Y., Luk, Fu Sang, de Mochel, Nabora Soledad Reyes, Gaudreault, Nathalie, Olivas, Victor R., Kumar, Nikit, Posada, Jessica M., Birkeland, Andrew C., Rapp, Joseph H., Raffai, Robert L.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346714/
https://ncbi.nlm.nih.gov/pubmed/22441102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.246389
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