cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac

BACKGROUND AND PURPOSE: Nephrotoxicity is the principal dose-limiting factor for cisplatin chemotherapy and is primarily associated with proximal tubular epithelial cells, including disruption of cell adhesions and induction of apoptosis. Cell adhesion and survival is regulated by, amongst other fac...

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Autors principals: Qin, Yu, Stokman, Geurt, Yan, Kuan, Ramaiahgari, Sreenivasa, Verbeek, Fons, de Graauw, Marjo, van de Water, Bob, Price, Leo S
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2012
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346244/
https://ncbi.nlm.nih.gov/pubmed/21745194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01594.x
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