Epac-Rap Signaling Reduces Cellular Stress and Ischemia-induced Kidney Failure

Renal ischemia-reperfusion injury is associated with the loss of tubular epithelial cell-cell and cell-matrix interactions which contribute to renal failure. The Epac-Rap signaling pathway is a potent regulator of cell-cell and cell-matrix adhesion. The cyclic AMP analogue 8-pCPT-2′-O-Me-cAMP has be...

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Detalhes bibliográficos
Main Authors: Stokman, Geurt, Qin, Yu, Genieser, Hans-Gottfried, Schwede, Frank, de Heer, Emile, Bos, Johannes L., Bajema, Ingeborg M., van de Water, Bob, Price, Leo S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2011
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083308/
https://ncbi.nlm.nih.gov/pubmed/21493776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010040423
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