cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac

BACKGROUND AND PURPOSE: Nephrotoxicity is the principal dose-limiting factor for cisplatin chemotherapy and is primarily associated with proximal tubular epithelial cells, including disruption of cell adhesions and induction of apoptosis. Cell adhesion and survival is regulated by, amongst other fac...

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Autores principales: Qin, Yu, Stokman, Geurt, Yan, Kuan, Ramaiahgari, Sreenivasa, Verbeek, Fons, de Graauw, Marjo, van de Water, Bob, Price, Leo S
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2012
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346244/
https://ncbi.nlm.nih.gov/pubmed/21745194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01594.x
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