cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac

BACKGROUND AND PURPOSE: Nephrotoxicity is the principal dose-limiting factor for cisplatin chemotherapy and is primarily associated with proximal tubular epithelial cells, including disruption of cell adhesions and induction of apoptosis. Cell adhesion and survival is regulated by, amongst other fac...

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Detalhes bibliográficos
Main Authors: Qin, Yu, Stokman, Geurt, Yan, Kuan, Ramaiahgari, Sreenivasa, Verbeek, Fons, de Graauw, Marjo, van de Water, Bob, Price, Leo S
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346244/
https://ncbi.nlm.nih.gov/pubmed/21745194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01594.x
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