Involvement of Polo-like Kinase 1 (Plk1) in Mitotic Arrest by Inhibition of Mitogen-activated Protein Kinase-Extracellular Signal-regulated Kinase-Ribosomal S6 Kinase 1 (MEK-ERK-RSK1) Cascade

Cell division is controlled through cooperation of different kinases. Of these, polo-like kinase 1 (Plk1) and p90 ribosomal S6 kinase 1 (RSK1) play key roles. Plk1 acts as a G(2)/M trigger, and RSK1 promotes G(1) progression. Although previous reports show that Plk1 is suppressed by RSK1 during meio...

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Main Authors: Li, Ran, Chen, Dian-Fu, Zhou, Rong, Jia, Sheng-Nan, Yang, Jin-Shu, Clegg, James S., Yang, Wei-Jun
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346105/
https://ncbi.nlm.nih.gov/pubmed/22427657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.312413
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