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Calpain 2 Regulates Akt-FoxO-p27(Kip1) Protein Signaling Pathway in Mammary Carcinoma

We investigated the role of the ubiquitously expressed calpain 2 isoform in breast tumor cell growth, migration, signaling, and tumorigenesis. RNAi-mediated knockdown of the capn2 transcript was used to manipulate expression of the catalytic subunit of calpain 2 in the AC2M2 mouse mammary carcinoma...

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Detalles Bibliográficos
Autores principales: Ho, Wai-chi, Pikor, Larissa, Gao, Yan, Elliott, Bruce E., Greer, Peter A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346101/
https://ncbi.nlm.nih.gov/pubmed/22427650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.349308
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