Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis

Isolated hepatocytes undergo lipoapoptosis, a feature of hepatic lipotoxicity, on treatment with saturated free fatty acids (FFA) such as palmitate (PA). However, it is unknown if palmitate is directly toxic to hepatocytes or if its toxicity is indirect via the generation of lipid metabolites such a...

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Bibliografiska uppgifter
Huvudupphovsmän: Kakisaka, Keisuke, Cazanave, Sophie C., Fingas, Christian D., Guicciardi, Maria E., Bronk, Steven F., Werneburg, Nathan W., Mott, Justin L., Gores, Gregory J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2012
Ämnen:
Liver and Biliary Tract
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345964/
https://ncbi.nlm.nih.gov/pubmed/21995961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00301.2011
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