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Insulin-induced generation of reactive oxygen species and uncoupling of nitric oxide synthase underlie the cerebrovascular insulin resistance in obese rats

Hyperinsulinemia accompanying insulin resistance (IR) is an independent risk factor for stroke. The objective is to examine the cerebrovascular actions of insulin in Zucker obese (ZO) rats with IR and Zucker lean (ZL) control rats. Diameter measurements of cerebral arteries showed diminished insulin...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Katakam, Prasad V G, Snipes, James A, Steed, Mesia M, Busija, David W
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345912/
https://ncbi.nlm.nih.gov/pubmed/22234336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.181
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