Impaired mitochondria-dependent vasodilation in cerebral arteries of Zucker obese rats with insulin resistance

Mitochondria affect cerebrovascular tone by activation of mitochondrial ATP-sensitive K(+) (K(ATP)) channels and generation of reactive oxygen species (ROS). Insulin resistance accompanying obesity causes mitochondrial dysfunction, but the consequences on the cerebral circulation have not been fully...

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Bibliographic Details
Main Authors: Katakam, Prasad V. G., Domoki, Ferenc, Snipes, James A., Busija, Anna R., Jarajapu, Yagna P. R., Busija, David W.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2009
Subjects:
Neurohumoral Control of Cardiovascular Function
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643987/
https://ncbi.nlm.nih.gov/pubmed/19005015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.90656.2008
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