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Insulin-induced generation of reactive oxygen species and uncoupling of nitric oxide synthase underlie the cerebrovascular insulin resistance in obese rats

Hyperinsulinemia accompanying insulin resistance (IR) is an independent risk factor for stroke. The objective is to examine the cerebrovascular actions of insulin in Zucker obese (ZO) rats with IR and Zucker lean (ZL) control rats. Diameter measurements of cerebral arteries showed diminished insulin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Katakam, Prasad V G, Snipes, James A, Steed, Mesia M, Busija, David W
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345912/
https://ncbi.nlm.nih.gov/pubmed/22234336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.181
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