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Solid-phase synthesis of branched oligoribonucleotides related to messenger RNA splicing intermediates.

The chemical synthesis of oligoribonucleotides containing vicinal (2'-5')- and (3'-5')-phosphodiester linkages is described. The solid-phase method, based on silyl-phosphoramidite chemistry, was applied to the synthesis of a series of branched RNA [(Xp)nA2' (pN)n3'(pN)n] related to the splicing inte...

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Publicat a:Nucleic Acids Res
Autors principals: Damha, M J, Ganeshan, K, Hudson, R H, Zabarylo, S V
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 1992
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC334572/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1480476/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.24.6565
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