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Repair synthesis by human cell extracts in cisplatin-damaged DNA is preferentially determined by minor adducts.
During reaction of cis-diamminedichloroplatinum(II) (cis-DDP) with DNA, a number of adducts are formed which may be discriminated by the excision-repair system. An in vitro excision-repair assay with human cell-free extracts has been used to assess the relative repair extent of monofunctional adduct...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
1992
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| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC334528/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1475197/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.23.6363 |
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