Repair Capacity for Platinum-DNA Adducts Determines the Severity of Cisplatin-Induced Peripheral Neuropathy

The pronounced neurotoxicity of the potent antitumor drug cisplatin frequently results in the onset of peripheral polyneuropathy (PNP), which is assumed to be initially triggered by platination products in the nuclear DNA of affected tissues. To further elucidate the molecular mechanisms, we analyze...

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Vydáno v:J Neurosci
Hlavní autoři: Dzagnidze, Anna, Katsarava, Zaza, Makhalova, Julia, Liedert, Bernd, Yoon, Min-Suk, Kaube, Holger, Limmroth, Volker, Thomale, Juergen
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673116/
https://ncbi.nlm.nih.gov/pubmed/17728458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0523-07.2007
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