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Repair synthesis by human cell extracts in cisplatin-damaged DNA is preferentially determined by minor adducts.
During reaction of cis-diamminedichloroplatinum(II) (cis-DDP) with DNA, a number of adducts are formed which may be discriminated by the excision-repair system. An in vitro excision-repair assay with human cell-free extracts has been used to assess the relative repair extent of monofunctional adduct...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1992
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC334528/ https://ncbi.nlm.nih.gov/pubmed/1475197 |
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