Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages

There is accumulating evidence that the complement activation product, C5a, can orchestrate cellular immune functions. IL-27 (p28/EBI3) is an emerging key player essential for regulating inflammatory responses and T cells. Here, we report that C5a robustly suppressed IL-27(p28) gene expression and r...

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Bibliografiska uppgifter
Huvudupphovsmän: Bosmann, Markus, Haggadone, Mikel D., Hemmila, Mark R., Zetoune, Firas S., Sarma, J. Vidya, Ward, Peter A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345104/
https://ncbi.nlm.nih.gov/pubmed/22491257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102914
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