Complement dependency of cardiomyocyte release of mediators during sepsis

We have recently shown that antibody-induced blockade of C5a, C5a receptors, or IL-17A greatly reduced the harmful outcomes of sepsis. In the current study, normal cardiomyocytes from young (300 g) male Sprague-Dawley rats responded in vitro to C5a (ED(50)=55 nM) with release of IL-6 and TNFα, peaki...

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Главные авторы: Atefi, Gelareh, Zetoune, Firas S., Herron, Todd J., Jalife, José, Bosmann, Markus, Al-Aref, Rami, Sarma, J. Vidya, Ward, Peter A.
Формат: Artigo
Язык:Inglês
Опубликовано: Federation of American Societies for Experimental Biology 2011
Предметы:
Research Communications
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114524/
https://ncbi.nlm.nih.gov/pubmed/21478262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-183236
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