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Complement dependency of cardiomyocyte release of mediators during sepsis
We have recently shown that antibody-induced blockade of C5a, C5a receptors, or IL-17A greatly reduced the harmful outcomes of sepsis. In the current study, normal cardiomyocytes from young (300 g) male Sprague-Dawley rats responded in vitro to C5a (ED(50)=55 nM) with release of IL-6 and TNFα, peaki...
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| Glavni autori: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Federation of American Societies for Experimental Biology
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3114524/ https://ncbi.nlm.nih.gov/pubmed/21478262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-183236 |
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