BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain

The bromodomain protein, BRD4, has been identified recently as a therapeutic target in acute myeloid leukemia, multiple myeloma, Burkitt’s lymphoma, NUT midline carcinoma, colon cancer, and inflammatory disease; its loss is a prognostic signature for metastatic breast cancer. BRD4 also contributes t...

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Autors principals: Devaiah, Ballachanda N., Lewis, Brian A., Cherman, Natasha, Hewitt, Michael C., Albrecht, Brian K., Robey, Pamela G., Ozato, Keiko, Sims, Robert J., Singer, Dinah S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345009/
https://ncbi.nlm.nih.gov/pubmed/22509028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120422109
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