Semisynthetic Neoclerodanes as Kappa Opioid Receptor Probes

Modification of the furan ring of salvinorin A (1), the main active component of Salvia divinorum, has resulted in novel neoclerodane diterpenes with opioid receptor affinity and activity. Conversion of the furan ring to an aldehyde at the C-12 position (5) has allowed for the synthesis of analogues...

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Autores principales: Lovell, Kimberly M., Vasiljevik, Tamara, Araya, Juan J., Lozama, Anthony, Prevatt-Smith, Katherine M., Day, Victor W., Dersch, Christina M., Rothman, Richard B., Butelman, Eduardo R., Kreek, Mary Jeanne, Prisinzano, Thomas E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344910/
https://ncbi.nlm.nih.gov/pubmed/22464684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.02.040
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