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Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Role of the Furan in Affinity for Opioid Receptors

Further synthetic modification of the furan ring of salvinorin A (1), the major active component of Salvia divinorum, has resulted in novel neoclerodane diterpenes with opioid receptor affinity and activity. A computational study has predicted 1 to be a reproductive toxicant in mammals and is sugges...

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Détails bibliographiques
Auteurs principaux: Simpson, Denise S., Lovell, Kimberly M., Lozama, Anthony, Han, Nina, Day, Victor W., Dersch, Christina M., Rothman, Richard B., Prisinzano, Thomas E.
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025038/
https://ncbi.nlm.nih.gov/pubmed/19707679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b905148a
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