GFAP-Cre-Mediated Transgenic Activation of Bmi1 Results in Pituitary Tumors

Bmi1 is a member of the polycomb repressive complex 1 and plays different roles during embryonic development, depending on the developmental context. Bmi1 over expression is observed in many types of cancer, including tumors of astroglial and neural origin. Although genetic depletion of Bmi1 has bee...

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Detalhes bibliográficos
Main Authors: Westerman, Bart A., Blom, Marleen, Tanger, Ellen, van der Valk, Martin, Song, Ji-Ying, van Santen, Marije, Gadiot, Jules, Cornelissen-Steijger, Paulien, Zevenhoven, John, Prosser, Haydn M., Uren, Anthony, Aronica, Eleonora, van Lohuizen, Maarten
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344841/
https://ncbi.nlm.nih.gov/pubmed/22574128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035943
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