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Germ-Line Recombination Activity of the Widely Used hGFAP-Cre and Nestin-Cre Transgenes
Herein we demonstrate with PCR, immunodetection and reporter gene approaches that the widely used human Glial Fibrillary Acidic Protein (hGFAP)-Cre transgene exhibits spontaneous germ-line recombination activity in leading to deletion in brain, heart and tail tissue with high frequency. The ectopic...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3857304/ https://ncbi.nlm.nih.gov/pubmed/24349371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082818 |
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