Germ-Line Recombination Activity of the Widely Used hGFAP-Cre and Nestin-Cre Transgenes

Herein we demonstrate with PCR, immunodetection and reporter gene approaches that the widely used human Glial Fibrillary Acidic Protein (hGFAP)-Cre transgene exhibits spontaneous germ-line recombination activity in leading to deletion in brain, heart and tail tissue with high frequency. The ectopic...

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Detalhes bibliográficos
Main Authors: Zhang, Jiong, Dublin, Pavel, Griemsmann, Stephanie, Klein, Alexandra, Brehm, Ralph, Bedner, Peter, Fleischmann, Bernd K., Steinhäuser, Christian, Theis, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857304/
https://ncbi.nlm.nih.gov/pubmed/24349371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082818
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