Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition

Por Koppens, Martijn AJ, Bounova, Gergana, Cornelissen-Steijger, Paulien, de Vries, Nienke, Sansom, Owen J, Wessels, Lodewyk FA, van Lohuizen, Maarten
Publicado no Oncotarget (2016)

BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

Por Puppe, Julian, Drost, Rinske, Liu, Xiaoling, Joosse, Simon A, Evers, Bastiaan, Cornelissen-Steijger, Paulien, Nederlof, Petra, Yu, Qiang, Jonkers, Jos, van Lohuizen, Maarten, Pietersen, Alexandra M
Publicado em 2009

EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer

Por Pietersen, Alexandra M, Horlings, Hugo M, Hauptmann, Michael, Langerød, Anita, Ajouaou, Abderrahim, Cornelissen-Steijger, Paulien, Wessels, Lodewijk F, Jonkers, Jos, Vijver, Marc J van de, van Lohuizen, Maarten
Publicado em 2008

GFAP-Cre-Mediated Transgenic Activation of Bmi1 Results in Pituitary Tumors

Por Westerman, Bart A., Blom, Marleen, Tanger, Ellen, van der Valk, Martin, Song, Ji-Ying, van Santen, Marije, Gadiot, Jules, Cornelissen-Steijger, Paulien, Zevenhoven, John, Prosser, Haydn M., Uren, Anthony, Aronica, Eleonora, van Lohuizen, Maarten
Publicado em 2012

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer

Por Nacerddine, Karim, Beaudry, Jean-Bernard, Ginjala, Vasudeva, Westerman, Bart, Mattiroli, Francesca, Song, Ji-Ying, van der Poel, Henk, Ponz, Olga Balagué, Pritchard, Colin, Cornelissen-Steijger, Paulien, Zevenhoven, John, Tanger, Ellen, Sixma, Titia K., Ganesan, Shridar, van Lohuizen, Maarten
Publicado em 2012

Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts

Por Kemper, Kristel, Krijgsman, Oscar, Cornelissen-Steijger, Paulien, Shahrabi, Aida, Weeber, Fleur, Song, Ji-Ying, Kuilman, Thomas, Vis, Daniel J, Wessels, Lodewyk F, Voest, Emile E, Schumacher, Ton NM, Blank, Christian U, Adams, David J, Haanen, John B, Peeper, Daniel S
Publicado no EMBO Mol Med (2015)

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

Por Müller, Judith, Krijgsman, Oscar, Tsoi, Jennifer, Robert, Lidia, Hugo, Willy, Song, Chunying, Kong, Xiangju, Possik, Patricia A., Cornelissen-Steijger, Paulien D.M., Foppen, Marnix H. Geukes, Kemper, Kristel, Goding, Colin R., McDermott, Ultan, Blank, Christian, Haanen, John, Graeber, Thomas G., Ribas, Antoni, Lo, Roger S., Peeper, Daniel S.
Publicado no Nat Commun (2014)

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts

Por Kemper, Kristel, Krijgsman, Oscar, Kong, Xiangjun, Cornelissen-Steijger, Paulien, Shahrabi, Aida, Weeber, Fleur, van der Velden, Daphne L., Bleijerveld, Onno B., Kuilman, Thomas, Kluin, Roel J.C., Sun, Chong, Voest, Emile E., Ju, Young Seok, Schumacher, Ton N.M., Altelaar, A.F. Maarten, McDermott, Ultan, Adams, David J., Blank, Christian U., Haanen, John B., Peeper, Daniel S.
Publicado no Cell Rep (2016)