Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition

EZH2 inhibitors have gained great interest for their use as anti-cancer therapeutics. However, most research has focused on EZH2 mutant cancers and recently adverse effects of EZH2 inactivation have come to light. To determine whether colorectal cancer cells respond to EZH2 inhibition and to explore...

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Опубликовано в: :Oncotarget
Главные авторы: Koppens, Martijn AJ, Bounova, Gergana, Cornelissen-Steijger, Paulien, de Vries, Nienke, Sansom, Owen J, Wessels, Lodewyk FA, van Lohuizen, Maarten
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2016
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342517/
https://ncbi.nlm.nih.gov/pubmed/27634879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12002
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