GFAP-Cre-Mediated Transgenic Activation of Bmi1 Results in Pituitary Tumors

Bmi1 is a member of the polycomb repressive complex 1 and plays different roles during embryonic development, depending on the developmental context. Bmi1 over expression is observed in many types of cancer, including tumors of astroglial and neural origin. Although genetic depletion of Bmi1 has bee...

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Hlavní autoři: Westerman, Bart A., Blom, Marleen, Tanger, Ellen, van der Valk, Martin, Song, Ji-Ying, van Santen, Marije, Gadiot, Jules, Cornelissen-Steijger, Paulien, Zevenhoven, John, Prosser, Haydn M., Uren, Anthony, Aronica, Eleonora, van Lohuizen, Maarten
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344841/
https://ncbi.nlm.nih.gov/pubmed/22574128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035943
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