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Mutant G protein α subunit activated by Gβγ: A model for receptor activation?
How receptors catalyze exchange of GTP for GDP bound to the Gα subunit of trimeric G proteins is not known. One proposal is that the receptor uses the G protein's βγ heterodimer as a lever, tilting it to pull open the guanine nucleotide binding pocket of Gα. To test this possibility, we designe...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC33437/ https://ncbi.nlm.nih.gov/pubmed/11344266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.101136198 |
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