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Mutant G protein α subunit activated by Gβγ: A model for receptor activation?

How receptors catalyze exchange of GTP for GDP bound to the Gα subunit of trimeric G proteins is not known. One proposal is that the receptor uses the G protein's βγ heterodimer as a lever, tilting it to pull open the guanine nucleotide binding pocket of Gα. To test this possibility, we designe...

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Detalles Bibliográficos
Main Authors: Rondard, Philippe, Iiri, Taroh, Srinivasan, Supriya, Meng, Elaine, Fujita, Toshiro, Bourne, Henry R.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC33437/
https://ncbi.nlm.nih.gov/pubmed/11344266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.101136198
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