Mutant G protein α subunit activated by Gβγ: A model for receptor activation?

How receptors catalyze exchange of GTP for GDP bound to the Gα subunit of trimeric G proteins is not known. One proposal is that the receptor uses the G protein's βγ heterodimer as a lever, tilting it to pull open the guanine nucleotide binding pocket of Gα. To test this possibility, we designed a m...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Rondard, Philippe, Iiri, Taroh, Srinivasan, Supriya, Meng, Elaine, Fujita, Toshiro, Bourne, Henry R.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33437/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11344266/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.101136198
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