Mutant G protein α subunit activated by Gβγ: A model for receptor activation?
How receptors catalyze exchange of GTP for GDP bound to the Gα subunit of trimeric G proteins is not known. One proposal is that the receptor uses the G protein's βγ heterodimer as a lever, tilting it to pull open the guanine nucleotide binding pocket of Gα. To test this possibility, we designed a m...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2001
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33437/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11344266/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.101136198 |
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