Receptors induce chemotaxis by releasing the βγ subunit of G(i), not by activating G(q) or G(s)

Many chemoattractants cause chemotaxis of leukocytes by stimulating a structurally distinct class of G protein-coupled receptors. To identify receptor functions required for chemotaxis, we studied chemotaxis in HEK293 cells transfected with receptors for nonchemokine ligands or for interleukin 8 (IL...

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Bibliographische Detailangaben
Hauptverfasser: Neptune, Enid R., Bourne, Henry R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences of the USA 1997
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC25031/
https://ncbi.nlm.nih.gov/pubmed/9405640
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