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Tightening of the ATP-binding sites induces the opening of P2X receptor channels
The opening of ligand-gated ion channels in response to agonist binding is a fundamental process in biology. In ATP-gated P2X receptors, little is known about the molecular events that couple ATP binding to channel opening. In this paper, we identify structural changes of the ATP site accompanying t...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3343472/ https://ncbi.nlm.nih.gov/pubmed/22473210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.75 |
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