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Tightening of the ATP-binding sites induces the opening of P2X receptor channels

The opening of ligand-gated ion channels in response to agonist binding is a fundamental process in biology. In ATP-gated P2X receptors, little is known about the molecular events that couple ATP binding to channel opening. In this paper, we identify structural changes of the ATP site accompanying t...

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Autori principali: Jiang, Ruotian, Taly, Antoine, Lemoine, Damien, Martz, Adeline, Cunrath, Olivier, Grutter, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343472/
https://ncbi.nlm.nih.gov/pubmed/22473210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.75
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